Enantioselective Synthesis of β-Trifluoromethyl-β-lactones via NHC-Catalyzed Ketene-Ketone Cycloaddition Reactions

摘要

The highly diastereo- and enantioselective synthesis of β-trifluoromethyl-β-lactones bearing two contiguous stereocenters was realized by chiral N-heterocyclic carbene-catalyzed formal cycloaddition reaction of alkyl(aryl)ketenes and trifluoromethyl ketones.