Organocatalytic Enantioselective Cascade Michael-Michael-Wittig Reactions of Phosphorus Ylides: One-Pot Synthesis of the all-cis Trisubstituted Cyclohexenecarboxylates via the [1+2+3] Annulation

摘要

The stereoselective synthesis of all-cis 5-nitro-4,6-diphenylcyclohex-1 -enecarboxylic ester has been achieved by an organocatalytic asymmetric Michael-Michael-Wittig cascade reaction of phosphorus ylides, nitroolefins, and alpha,beta-unsaturated aldehydes with excellent enantioselectivities (up to >99% ee).