Efficient and Regioselective One-Pot Synthesis of 3-Substituted and 3,5-Disubstituted Isoxazoles

摘要

A series of 3-substituted and 3,5-disubstituted Isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with alpha,beta-unsaturated aldehydes/ketones. This novel strategy Is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.