Development and Validation of an Immuno-PET Tracer as a Companion Diagnostic Agent for Antibody-Drug Conjugate Therapy to Target the CA6 Epitope

Ilovich Ohad; Natarajan Arutselvan; Hori Sharon; Sathirachinda Ataya; Kimura Richard; Srinivasan Ananth; Gebauer Mathias; Kruip Jochen; Focken Ingo; Lange Christian; Carrez Chantal; Sassoon Ingrid; Blanc Veronique; Sarkar Susanta K.; Gambhir Sanjiv S.

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Development and Validation of an Immuno-PET Tracer as a Companion Diagnostic Agent for Antibody-Drug Conjugate Therapy to Target the CA6 Epitope

机译：Immuno-PET示踪剂的开发和验证，作为针对抗体-药物结合疗法靶向CA6表位的伴侣诊断剂

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Purpose: To develop and compare three copper 64 (Cu-64)-labeled antibody fragments derived from a CA6-targeting antibody (huDS6) as immuno-positron emission tomography (immuno-PET)-based companion diagnostic agents for an antibody-drug conjugate by using huDS6.

机译：目的：开发和比较源自靶向CA6的抗体（huDS6）的三个铜64（Cu-64）标记的抗体片段，作为基于免疫正电子发射断层扫描（immuno-PET）的抗体-药物偶联物的伴随诊断剂通过使用huDS6。

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《Radiology》 |2015年第1期|共8页
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Ilovich Ohad; Natarajan Arutselvan; Hori Sharon; Sathirachinda Ataya; Kimura Richard; Srinivasan Ananth; Gebauer Mathias; Kruip Jochen; Focken Ingo; Lange Christian; Carrez Chantal; Sassoon Ingrid; Blanc Veronique; Sarkar Susanta K.; Gambhir Sanjiv S.;
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1. Development and Validation of an Immuno-PET Tracer as a Companion Diagnostic Agent for Antibody-Drug Conjugate Therapy to Target the CA6 Epitope [J] . Ilovich Ohad, Natarajan Arutselvan, Hori Sharon, Radiology . 2015,第1期

机译：Immuno-PET示踪剂的开发和验证，作为针对抗体-药物结合疗法靶向CA6表位的伴侣诊断剂
2. Antibody-Drug Conjugates and Small Molecule-Drug Conjugates: Opportunities and Challenges for the Development of Selective Anticancer Cytotoxic Agents [J] . Casi Giulio, Neri Dario Journal of Medicinal Chemistry . 2015,第22期

机译：抗体-药物结合物和小分子-药物结合物：选择性抗癌细胞毒剂开发的机遇与挑战
3. Development of a Novel EGFR-Targeting Antibody-Drug Conjugate for Pancreatic Cancer Therapy [J] . Li Zhuanglin, Wang Mingxue, Yao Xuejing, Targeted oncology . 2019,第1期

机译：用于胰腺癌疗法的新型EGFR靶向抗体 - 药物缀合物的发展
4. Chemical proteomic identification of targets for antibody-drug conjugate based therapy in acute myeloid leukemia [C] . V. Strassberger, T. Fugmann, D. Neri American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：基于抗体药物缀合物的靶向急性髓性白血病疗法的化学蛋白质组学鉴定
5. Part I. Design, synthesis and biological evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents. Part II. Development of novel taxoid-based drug conjugates and theranostic imaging agents towards tumor-targeted chemotherapy. [D] . Park, Bora. 2014

机译：第一部分：针对FtsZ作为抗结核药的新型2,5,6-三取代苯并咪唑的设计，合成和生物学评估。第二部分新型基于紫杉醇的药物结合物和治疗诊断剂在肿瘤靶向化疗中的应用。
6. Development and Validation of an Immuno-PET Tracer as a CompanionDiagnostic Agent for Antibody-Drug Conjugate Therapy to Target the CA6Epitope [O] . Ohad Ilovich, Arutselvan Natarajan, Sharon Hori, -1

机译：作为伴侣的Immuno-PET示踪剂的开发和验证靶向CA6的抗体-药物结合疗法诊断剂表位
7. Development and Validation of an Immuno-PET Tracer as a Companion Diagnostic Agent for Antibody-Drug Conjugate Therapy to Target the CA6 Epitope [O] . Ohad Ilovich, Arutselvan Natarajan, Sharon Hori, 2015

机译：免疫宠物示踪剂作为抗体 - 药物缀合物治疗靶向CA6表位的伴随诊断剂的开发和验证

Development and Validation of an Immuno-PET Tracer as a Companion Diagnostic Agent for Antibody-Drug Conjugate Therapy to Target the CA6 Epitope

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