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首页> 外文期刊>Nucleic Acids Research >The Mouse Genome Database genotypes::phenotypes.
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The Mouse Genome Database genotypes::phenotypes.

机译:小鼠基因组数据库的基因型::表型。

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摘要

The Mouse Genome Database (MGD, http://www.informatics.jax.org/), integrates genetic, genomic and phenotypic information about the laboratory mouse, a primary animal model for studying human biology and disease. Information in MGD is obtained from diverse sources, including the scientific literature and external databases, such as EntrezGene, UniProt and GenBank. In addition to its extensive collection of phenotypic allele information for mouse genes that is curated from the published biomedical literature and researcher submission, MGI includes a comprehensive representation of mouse genes including sequence, functional (GO) and comparative information. MGD provides a data mining platform that enables the development of translational research hypotheses based on comparative genotype, phenotype and functional analyses. MGI can be accessed by a variety of methods including web-based search forms, a genome sequence browser and downloadable database reports. Programmatic access is available using web services. Recent improvements in MGD described here include the unified mouse gene catalog for NCBI Build 37 of the reference genome assembly, and improved representation of mouse mutants and phenotypes.
机译:小鼠基因组数据库(MGD,http://www.informatics.jax.org/)整合了有关实验室小鼠的遗传,基因组和表型信息,这是研究人类生物学和疾病的主要动物模型。 MGD中的信息可从多种来源获得,包括科学文献和外部数据库,例如EntrezGene,UniProt和GenBank。除了从已出版的生物医学文献和研究人员的论文中精选出的有关小鼠基因的表型等位基因信息的广泛收集之外,MGI还包括小鼠基因的全面表示,包括序列,功能(GO)和比较信息。 MGD提供了一个数据挖掘平台,该平台可以根据比较基因型,表型和功能分析来开发翻译研究假设。可以通过多种方法访问MGI,包括基于Web的搜索表,基因组序列浏览器和可下载的数据库报告。可以使用Web服务进行程序访问。这里描述的MGD的最新改进包括参考基因组装配的NCBI Build 37的统一小鼠基因目录,以及小鼠突变体和表型的改进表示。

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