首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >DYNAMIC CHANGES IN EXTRACELLULAR RELEASE OF GABA AND GLUTAMATE IN THE LATERAL SEPTUM DURING SOCIAL PLAY BEHAVIOR IN JUVENILE RATS: IMPLICATIONS FOR SEX-SPECIFIC REGULATION OF SOCIAL PLAY BEHAVIOR
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DYNAMIC CHANGES IN EXTRACELLULAR RELEASE OF GABA AND GLUTAMATE IN THE LATERAL SEPTUM DURING SOCIAL PLAY BEHAVIOR IN JUVENILE RATS: IMPLICATIONS FOR SEX-SPECIFIC REGULATION OF SOCIAL PLAY BEHAVIOR

机译:幼年大鼠社交游戏行为过程中横向皮脂中GABA和谷氨酸盐胞外释放的动态变化:对社交游戏行为的性别特异性调节的意义

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Social play is a motivated and rewarding behavior that is displayed by nearly all mammals and peaks in the juvenile period. Moreover, social play is essential for the development of social skills and is impaired in social disorders like autism. We recently showed that the lateral septum (LS) is involved in the regulation of social play behavior in juvenile male and female rats. The LS is largely modulated by GABA and glutamate neurotransmission, but their role in social play behavior is unknown. Here, we determined whether social play behavior is associated with changes in the extracellular release of GABA and glutamate in the LS and to what extent such changes modulate social play behavior in male and female juvenile rats. Using intracerebral microdialysis in freely behaving rats, we found no sex difference in extracellular GABA concentrations, but extracellular glutamate concentrations are higher in males than in females under baseline conditions and during social play. This resulted in a higher glutamate/GABA concentration ratio in males vs. females and thus, an excitatory predominance in the LS of males. Furthermore, social play behavior in both sexes is associated with significant increases in extracellular release of GABA and glutamate in the LS. Pharmacological blockade of GABA-A receptors in the LS with bicuculline (100 ng/0.5 mu l, 250 ng/0.5 mu l) dose-dependently decreased the duration of social play behavior in both sexes. In contrast, pharmacological blockade of ionotropic glutamate receptors (NMDA and AMPA/kainate receptors) in the LS with AP-5 + CNQX (2 mM + 0.4 mM/0.5 mu l, 30 mM + 3 mM/0.5 mu l) dosedependently decreased the duration of social play behavior in females, but did not alter social play behavior in males. Together, these data suggest a role for GABA neurotransmission in the LS in the regulation of juvenile social play behavior in both sexes, while glutamate neurotransmission in the LS is involved in the sex-specific regulation of juvenile social play behavior. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
机译:社交活动是一种激励和奖励的行为,几乎所有的哺乳动物和幼年时期的高峰期都表现出这种行为。此外,社交活动对于社交技能的发展至关重要,在自闭症等社交疾病中会受到损害。我们最近表明,外侧隔片(LS)参与了幼年雌性和雌性大鼠社交行为的调节。 LS在很大程度上受GABA和谷氨酸神经传递的调节,但它们在社交行为中的作用尚不清楚。在这里,我们确定社交游戏行为是否与LS中GABA和谷氨酸的细胞外释放变化有关,以及这种变化在多大程度上调节了雄性和雌性幼鼠的社交游戏行为。在行为自由的大鼠中进行脑内微透析,我们发现细胞外GABA浓度没有性别差异,但是在基线条件下和社交活动中,男性的细胞外谷氨酸浓度高于女性。这导致男性与女性的谷氨酸/ GABA浓度比更高,因此在男性的LS中兴奋性占优势。此外,男女的社交行为与LS中GABA和谷氨酸的细胞外释放的显着增加有关。双小分子(100 ng / 0.5μl,250 ng / 0.5μl)在LS中对GABA-A受体的药理阻断剂量依赖性地减少了男女的社交行为的持续时间。相比之下,使用AP-5 + CNQX(2 mM + 0.4 mM / 0.5μl,30 mM + 3 mM / 0.5μl)的LS中的离子型谷氨酸受体(NMDA和AMPA /海藻酸酯受体)的药理阻断剂量依赖性地降低了女性社交游戏行为的持续时间,但并未改变男性社交游戏行为。总之,这些数据表明,LS中的GABA神经传递在调节男女两性的青少年社交行为中起着作用,而LS中的谷氨酸神经传递与青少年社交行为的性别特异性调节有关。 (C)2015年IBRO。由Elsevier Ltd.出版。保留所有权利。

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