A_1 ADENOSINE RECEPTOR MODULATION OF CHEMICALLY AND ELECTRICALLY EVOKED LUMBAR LOCOMOTOR NETWORK ACTIVITY IN ISOLATED NEWBORN RAT SPINAL CORDS

摘要

It is not well-studied how the ubiquitous neuro-modulator adenosine (ADO) affects mammalian locomotor network activities. We analyzed this here with focus on roles of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX)-sensitive Ar type ADO receptors. For this, we recorded field potentials from ventral lumbar nerve roots and electrically stimulated dorsal roots in isolated newborn rat spinal cords. At >=25muM, bath-applied ADO slowed synchronous bursting upon blockade of anion-channel-mediated synaptic inhibition by bicuculline (20 muM) plus strychnine (1 muM) and this depression was countered by DPCPX (1muM) as tested at 100 muM ADO. ADO abolished this disinhibited rhythm at >=500muM.