Nongenomic, glucocorticoid receptor-mediated regulation of serotonin transporter cell surface expression in embryonic stem cell derived serotonergic neurons

摘要

Dysregulation of the hypothalamus-pituitary-adrenal (HPA)-axis and the serotonergic (5-hydroxytryptamin, 5-HT) system have both been linked to the etiology and maintenance of anxiety and affective disorders [15,27]. One pivotal molecule in the 5-HT system is the serotonin transporter (5-HTT). 5-HTT is distributed between the cell surface and intracellular membranous structures and ongoing trafficking between these two compartments has been reported [5]. Only 5-HTT located in the cell membrane terminates serotonergic neurotransmission by the re-uptake of 5-HT from the extracellular space.