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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >SUMO-1 immunoreactivity co-localizes with phospho-Tau in APP transgenic mice but not in mutant Tau transgenic mice.
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SUMO-1 immunoreactivity co-localizes with phospho-Tau in APP transgenic mice but not in mutant Tau transgenic mice.

机译:SUMO-1免疫反应性在APP转基因小鼠中与磷酸Tau共定位,但在突变Tau转基因小鼠中不定位。

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摘要

Sumoylation is a post-translational modification process that is supposed to be implicated in the pathogenesis of several neurodegenerative diseases. Recently, the microtubule-associated protein Tau was identified as a target for sumoylation in the analysis of the transfected cells. We investigated the localization of SUMO-1 protein in APP transgenic mice and mutant Tau transgenic mice, and found that SUMO-1 immunoreactivity was co-localized with phosphorylated Tau aggregates in amyloid plaques of APP transgenic mice. By contrast, no SUMO-1 immunoreactivity was observed in phosphorylated Tau aggregates of mutant Tau transgenic mice. The contribution of sumoylation to the neurodegeneration in Alzheimer's disease will be further elucidated via the analysis of APP transgenics.
机译:Sumoylation是翻译后修饰过程,被认为与几种神经退行性疾病的发病机理有关。最近,在转染细胞的分析中,微管相关蛋白Tau被确定为sumoylation的目标。我们调查了SUMO-1蛋白在APP转基因小鼠和突变Tau转基因小鼠中的定位,发现SUMO-1免疫反应性与磷酸化的Tau聚集体在APP转基因小鼠的淀粉样斑块中共定位。相反,在突变的Tau转基因小鼠的磷酸化的Tau聚集体中未观察到SUMO-1免疫反应性。通过APP转基因的分析将进一步阐明SUMO化对阿尔茨海默氏病神经变性的贡献。

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