Direct Highly Regioselective Functionalization of Carbohydrates: A Three-Component Reaction Combining the Dissolving and Catalytic Efficiency of Ionic Liquids

摘要

An unprecedented regioselective functionalization of unprotected polyols has been realized with the use of an ionic liquid NHC precatalyst. The protocol is robust, scalable, and the products can be isolated in good to excellent yields without chromatography. Moreover, the methodology enables successful recycling of the catalyst.