Copper-Catalyzed Domino Reaction Involving C-C Bond Cleavage To Construct 2-Aryl Quinazolinones

摘要

A copper-catalyzed approach for the synthesis of 2-aryl-quinazolinones through a domino reaction involving C-C bond cleavage is described. This protocol involves intramolecular C-C bond cleavage to construct 2-aryl-quinazolinones, which may offer an alternative method to prepare medically important quinazolinone derivatives and a new strategy for C-C bond cleavage. Besides C-C bond cleavage, this domino reaction includes N-arylation and benzylic C-H amidation.