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首页> 外文期刊>European journal of inorganic chemistry >Water-Soluble (Phosphane)gold(I) Complexes - Applications as Recyclable Catalysts in a Three-Component Coupling Reaction and as Antimicrobial and Anticancer Agents
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Water-Soluble (Phosphane)gold(I) Complexes - Applications as Recyclable Catalysts in a Three-Component Coupling Reaction and as Antimicrobial and Anticancer Agents

机译:水溶性(磷)金(I)配合物-在三组分偶联反应中作为可循环使用的催化剂以及在抗菌剂和抗癌剂中的应用

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摘要

Water-soluble compounds of the type [AuCl(PR3)] with alkyl-bis(m-sulfonated-phenyl) (MC6H4SO3Na)(2) and dialkyl-(m-sulfonated-phenyl) (mC(6)H(4)SO(3)Na) (R = nBu, Cp) phospbanes have been prepared. Dialkylphosphane compounds generate water-soluble nanoparticles of 10-15 nm radius when dissolved in water. These air-stable complexes have been evaluated as catalysts in the synthesis of propargylamines by a three-component coupling reaction of aldehydes, amines, and alkynes in water. The antimicrobial activity of the new complexes against gram-positive and gram-negative bacteria and yeast has been evaluated. The new compounds display moderate to high antibacterial activity. The more lipophilic compounds are also potent against fungi. Their cytotoxic properties have been analyzed in vitro by utilizing human Jurkat T-cell acute lymphoblastic leukemia cells. Compounds with dialkyl-(m-sulfonated-phenyl) (mC(6)H(4)SO(3)Na) phosphanes displayed moderate to high cytotoxicity on this cell line. The cell death mechanism involves mainly early apoptosis. The catalytic/biological activity of the previously described compound with commercial m-trisulfonated-triphenylphosphane [AuCl(TPPTS)] (6) has also been evaluated to compare the effects of the higher basicity and lipophilicity of the alkyl- and dialkyl-(m-sulfonated-phenyl)phosphanes on these new compounds.
机译:[AuCl(PR3)]型水溶性化合物与烷基双(间磺化苯基)(MC6H4SO3Na)(2)和二烷基-(间磺化苯基)(mC(6)H(4)SO (3)Na)(R = nBu,Cp)磷酰氯已制备。当溶解在水中时,二烷基膦化合物生成半径为10-15 nm的水溶性纳米颗粒。这些空气稳定的配合物已通过醛,胺和炔烃在水中的三组分偶联反应在炔丙基胺合成中用作催化剂。已经评估了新复合物对革兰氏阳性和革兰氏阴性细菌和酵母的抗菌活性。新化合物显示出中等至高的抗菌活性。亲脂性更高的化合物也对真菌有效。通过利用人Jurkat T细胞急性淋巴细胞白血病细胞体外分析了它们的细胞毒性特性。具有二烷基-(间磺化苯基)(mC(6)H(4)SO(3)Na)膦的化合物在此细胞系上显示中度至高细胞毒性。细胞死亡机制主要涉及早期凋亡。还评估了上述化合物与商用间三磺化三苯膦[AuCl(TPPTS)](6)的催化/生物活性,以比较烷基和二烷基-(m-这些新化合物上的磺化苯基)膦。

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