BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy

Rivera Jose Carlos; Noueihed Baraa; Omri Samy; Barrueco Jose; Hilberg Frank; Chemtob Sylvain

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BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy

机译：BIBF1120（Vargatef）在血管增生性视网膜病变模型中抑制视网膜前新生血管形成并增强正常血管形成

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摘要

PURPOSE. This study evaluated the effects of BIBF1120, a novel triple angiokinase inhibitor against pathological retinal neovascularization.

机译：目的。这项研究评估了BIBF1120（一种新型的三联血管激酶抑制剂）对病理性视网膜新血管形成的作用。

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《Investigative ophthalmology & visual science》 |2015年第13期|共11页
作者
Rivera Jose Carlos; Noueihed Baraa; Omri Samy; Barrueco Jose; Hilberg Frank; Chemtob Sylvain;
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正文语种 eng
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BIBF1120; Vargatef; nintedanib; tyrosine kinase inhibitor; neovascularization; antiangiogenic; retinopathy of prematurity;

机译：BIBF1120;Vargatef;nintedanib;酪氨酸激酶抑制剂;新生血管;抗血管生成;早产儿视网膜病变;

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专利

1. BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy [J] . Jos?? Carlos Rivera, Baraa Noueihed, Samy Omri, Investigative ophthalmology & visual science . 2015,第13期

机译：BIBF1120（Vargatef）在血管增生性视网膜病变模型中抑制视网膜前新生血管形成并增强正常血管形成
2. T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. [J] . Banin E, Dorrell MI, Aguilar E, Investigative ophthalmology & visual science . 2006,第5期

机译：T2-TrpRS可抑制视网膜前新生血管，并增强OIR的生理性血管再生长，这是通过一种新的定量方法进行评估的。
3. Aucuba japonica extract inhibits retinal neovascularization in a mouse model of oxygen‐induced retinopathy, with its bioactive components preventing VEGF‐induced retinal vascular hyperpermeability [J] . Eunsoo Jung, Woo Kwon Jung, Su‐Bin Park, Food Science & Nutrition . 2020,第6期

机译：Aucuba japonica提取物在氧诱导的视网膜病变小鼠模型中抑制视网膜新生血管，其生物活性组分预防VEGF诱导的视网膜血管超透性
4. Platelet-activating factor enhances the expression of vascular endothelial growth factor in normal human astrocytes under hypoxia [C] . Hidemi Yoshida, Tadaatsu Imaizumi, Kunikazu Tanji, Hirosaki International Forum of Medical Science . 2003

机译：血小板活化因子增强了缺氧下正常人星形胶质细胞中血管内皮生长因子的表达
5. Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity. [D] . Solomon, Evertz Stenson. 2007

机译：白细胞介素10（IL-10）选择性抑制早产儿视网膜病变的鼠模型中的新生血管形成。
6. Aucuba japonica extract inhibits retinal neovascularization in a mouse model of oxygen‐induced retinopathy with its bioactive components preventing VEGF‐induced retinal vascular hyperpermeability [O] . Eunsoo Jung, Woo Kwon Jung, Su‐Bin Park, 2020

机译：优质粳米提取物可在氧致视网膜病变的小鼠模型中抑制视网膜新血管形成其生物活性成分可防止VEGF引起的视网膜血管通透性过高
7. BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy [O] . José Carlos Rivera, Baraa Noueihed, Samy Omri, 2015

机译：BiBF1120（Vargatef）抑制特定新血管化并增强血管抑制性视网膜病变模型中的正常血管化

BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy

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