Neutral and cationic osmium(II)-arene metallodendrimers: Synthesis, characterisation and anticancer activity

摘要

Two neutral and two cationic half-sandwich Os(II)-arene metallodendrimers, of general formula [DABPPI-{(η~6-p-cym)Os((C_7H_5NO)-k~2-N,O)Cl}_n] and [DAB-PPI-{(η~6-p-cym)Os((C_6H_5N_2)-k~2-N,N)Cl}_n][PF_6]_n (where n = 4 (G1) or 8 (G2)) have been synthesised. In addition, two cationic half-sandwich Os(II)-arene metallodendrimers, containing PTA (1,3,5-triaza-7-phosphatricyclo[3.3.1.1.] decane), of general formula [DAB-PPI-{(η~6-p-cym)Os((C_7H_5NO)-k~2-N,O)PTA}_n][PF_6]_n are also reported. All complexes have been characterised using analytical (i.e. HR-ESI or EI mass spectrometry and elemental analysis) and spectroscopic (i.e. ~1H, ~(13)C{~1H} NMR and infrared) methods. Model mononuclear analogues have been prepared and their molecular structures determined by single-crystal X-ray crystallography. The cytotoxicity of the complexes were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines and some display moderate activity.