Novel Pt(II) anticancer agents and their Pd(II) analogues: syntheses, crystal structures, reactions with nucleobases and cytotoxicities

摘要

Five novel cisplatin analogues as well as their equivalent palladium compounds were prepared using the chelating ligands 2-(2-pyridyl)benzimidazole(pbi), 2-(2-pyridyl)-5,6-dimethylbenzimidazole (pdbi), 2-(2-pyrazyl)-5,6-dimethylbenzimidazole (padbi), bis(pyridine-2-yl)methane (bpm), and (2,2'-dipyridyl)propylamine (dppa).