Synthesis, Characterization and Antibacterial Activity of Some New 3-{[4-(2-Methoxyphenyl)piperazin-1-yl]sulfonyl}benzohydrazide-hydrazone Derivatives

摘要

In this article, a series of novel derivatives of 3-{[4-(2-methoxyphenyl)piperazin-1-yl]sulfonyl}benzohydrazide have been reported. The structures of all compounds have been evaluated by elemental analysis and spectral analysis (1R, MS and ~1H NMR). All the compounds have been screened for antimicrobial activity against two Gram-positive bacteria viz., Staphylococcus aureus and Staphylococcus pyogenes, two Gram-negative bacteria viz., Escherichia coli and Pseudomonas aeruginosa. Compounds 6g (R = 4-NO2) and 6h (R = 2-OH, 3-OMe) exhibited excellent antibacterial activity, while the compounds 6a (R = H), 6b (R = 2-OMe), 6f (R = 4-OMe), 6i (R = 3,4-diethoxy) and 6j (R = 3-OMe, 4-OEt) displayed good antibacterial activity.