One-Pot Three Component Synthesis of Highly Functionalized Novel 1,8-Naphthyridine Derivatives from Substituted 2-Aminopyridines, Aldehydes and Malononitrile

摘要

Protocol for one-pot three component cascade synthesis was planned to achieve the highly functionalized novel 1,8-naphthyridine derivatives from readily available starting material. Substituted aldehydes and malononitrile were refluxed in THF followed by the addition of substituted 2-aminopyridine to obtain highly functionalized novel 1-8-naphthyridine (12a-12x), in good to excellent yields. The structures of the newly synthesized 1,8-naphthyridine derivatives have been established on the basis of analytical (C, H, N) and spectroscopic ('H NMR and ~(13)C NMR) data. These fully functionalized heterocycles would be employed as versatile synthons for further chemical transformation and eventually, screened for biological studies.