Poly(aryl ether) Dendritic Structures Based on 1,4,8,11-Tetraazacyclotetradecane Core: Synthesis, Characterization, Photophysical Properties and Biological activity

摘要

This work describes the synthesis of two new dendrimers consisting of a 1,4,8,11-tetraazacyclotetradecane (cyclam) core appended with poly(aryl ether) dendritic structures carrying a donor (4-methyl-7-hydroxycoumarin) on the surface. Its structure was determined by 'H NMR, ~(13)C NMR and elemental analysis. The photophysical properties of the series of poly(aryl ether) dendrimers have been determined and the effect of the generation number on the absorption and emission properties of the synthesized dendritic structures was investigated. As the chromophore group number on the surface of the dendritic structure increased, molar absorptivity coefficients and emission intensities of the structures were found to increase. The prepared dendritic structures were tested for their antimicrobial activity against, Salmonella typhimurium NRRLB, Micrococcus luteus, Pseudomonas aeruginosa, Enterococcus fecalis ATCC-29212, Bacillus cereus ATCC-117787, Klepsiella pneumonia, Bacillus subtilis NRS-744, Proteus vulgaris, Yersinia enterolitica and Saccharomyces cereviciae, Synthesized dendritic structures showed moderate activity against different strains of bacteria.