Design and Study of Ritonavir Buoyant Microspheres by Eudragit S100 Polymer

摘要

Multiple unit buoyant delivery systems can be distributed widely throughout the gastrointestinal tract, providing the possibility of achieving longer lasting and reliable release of drug from the formulation. The aim of the present study was to prepare and evaluate buoyant microspheres of ritonavir using eudragit S100 polymer. The formulated microspheres were characterized for their yield, particle size, incorporation efficiency, in vitro buoyancy, in vitro Release characteristics were studied by 0.1 N HC1 and found to be in the range of 63 to 86 %. This investigation concludes that ritonavir loaded buoyant microspheres were successfully formulated.