Synthesis, Characterization and Biological Activity of Some New Acetohydrazide Derivatives via 3,3'-Dimethylbenzidine

摘要

Schiff base (1): 2,2'-(3,3'-dimethylbiphenyl-4,4'-diyl)bis(azan-1-yl-1-yliderie)diacetic acid was obtained by condensation of 3,3'-dimethylbenzidine with glyoxalic acid in ethanol. The esterfication of 1 with ethanol in presence of sulfuric acid gave the ester (2): diphenyl-2,2'-(3,3'-dimethylbiphenyl-4,4'-diyl)bis(azan-1-y]-1-ylidene)diacetate, then converted this ester to the acid hydrazide by reaction with hydrazine hydrate in ethanol to gave (3): 2,2'-(3,3'-dimethylbiphenyl-4,4'-diyl)bis(azan-1-yl-1-ylidene)diacetohydrazide,which was reacted with substituted aldehydes in ethanol to give the corresponding Schiff bases (4 a,b,c): 2,2'-(3,3'-dimethylbiphenyl-4,4'-diyl)bis(azan-1-yl-1-ylidine)bis(N'-(3-alkyl-4-hydroxybenzyIidene)acetohydrazide). The prepared compounds were characterized by spectral methods and Schiff bases were screened for antibacterial activity.