Microwave Assisted Synthesis of Pyridin-1-ium Salt of 6-Nitroquinazolin-4-one and its 6-Amino Analog under Ultrasonic Irradiation

摘要

The new compounds of quinazolin-4-one derivative i.e., 2-methyl-6-nitroquinazolin-4-one substituted pyridin-1-ium salt at methyl group and its 6-amino analog have been synthesized. Microwave irradiation of solution of 2-bromomethyl-6- nitroquinazolin-4-one and pyridine in acetonitrile for 3 min afforded l-[(6-nitroquinazolin-4-one-2-yl)methyl]pyridin-l-ium bromide; and nitro reduction of the product with iron in ethanol/aeetic acid/water under ultrasonic irradiation afforded 1 -[(6-aminoquinazolin-4-one-2-yl)methyl]pyridin-1 -ium bromide. The structure of the synthesized compounds were confirmed on the basis of FT-IR, ~1H NMR and ~(13)C NMR data.