Preparation and Characterization of Blood Substitutes Based on Amphiphilic Biodegradable Copolymers

摘要

A biodegradable hemoglobin nanoparticles based on the copolymers of MPEG-b-PLA was prepared by self-assemble. The optimization conditions were obtained that the hemoglobin was encapsulated in the polymersomes. The hemoglobin nanoparticles with different states dated in the polymersomes can be mutual transformed under different gas atmosphere was observed by UV spectra. While the partial pressure was increased, the oxy-hemoglobin was gradually transformed from deoxy-hemoglobin.