A Novel Preparation and Purification of Penta-Substituted 6-O-Propyl-β-cyclodextrin

摘要

A synthetic process about propyl-β-cyclodextrins has been investigated through the reaction between β-cyclodextrin and dipropyl carbonate by anhydrous potassium carbonate as catalyst in DMF, penta-substituted 6-O-propyl-β-cyclodextrin was purified by silica gel chromatography. The structures of product were characterized by TLC, IR, MS, ~1H NMR and ~(13)C NMR. Mass spectra and ~1H NMR proved the average degree of substitution of propyl-β-cyclodextrin is 5. ~(13)C NMR proved the position of propyl at 6-position.