Theoretical Analyses of Glibenclamide-Estradiol Derivative and Its Relationship with Some Physico-chemical Descriptors

摘要

A new glibenclarnide-estradiol conjugate was synthesized by the reaction of glibenclamide-succinate and estradiol-ethylenediamine derivative using N,N'-diciclohexylcarbodiimide/p-toluensulfonic acid as catalysts. In order to evaluate the degree of lipophilicity and its relationship with some physicochemical descriptors involved in its chemical structure, the ACD log P and KOWWIN methods were used. The results showed an increase in the values of these physicochemical parameters for the glibenclarnide-estradiol conjugate in comparison with glibenclamide and glibenclamide-succinate. These data suggest a relationship between the evaluated physicochemical parameters and the degree of lipophilicity of the glibenclarnide-estradiol conjugate.