Preliminary in vitro Cytotoxic Assay on HepG2 and Antibacterial Screening Activity: Synthesis and Characterization of Organotin(IV) Complexes Derivatives of 2-Methyl-3-nitrobenzoic Acid

摘要

Three organotin(IV) carboxylate complexes derivatives of 2-methyl-3-nitrobenzoic acid (HL) have been successfully synthesized and characterized quantitatively and qualitatively. The complexes obtained are screened for their preliminary in vitro cytotoxic assay on human liver hepatocellular carcinoma cells (HepG2) and antibacterial screening activity. Results of the infrared and NMR spectroscopy on the acid and complexes showed that the coordination took place via oxygen atoms from the carboxylate anions. With the exceptional case, based on the spectroscopy studies indicated that one methanol molecule also take part in the coordination to tin(IV) atom moiety in complex 3 resulting the tin(IV) atom exhibited five coordination in solid state. From the preliminary in vitro cytotoxic assay on HepG2 and antibacterial screening activity, triphenyltin(IV)(complex 3) showed slightly better activity compared to diorganotin(IV) complexes (1 and 2).