Highly rifampin-resistant Listeria monocytogenes isolated from a patient with prosthetic bone infection

摘要

Listeriosis is a rare but severe food-borne infection due to Listeria monocytogenes. L. monocytogenes is naturally susceptible to a wide range of antibiotics, including penicillins, aminoglyco-sides, tetracyclines, macrolides, co-trimoxazole, linezolid, moxi-floxacin, glycopeptides, and rifampin, but not to cephalosporins (1-3). L. monocytogenes resistance to antimicrobials is rare; it was estimated to be around 1.3% in 4,668 clinical isolates tested in the National Reference Centre for Listeria (NRCL) (3), involving mostly resistance to fluoroquinolones but not rifampin (1, 3-5).