Achieving High Resolution Ion Mobility Separations Using Traveling Waves in Compact Multiturn Structures for Lossless Ion Manipulations

摘要

We report on ion mobility (IM), separations achievable using traveling waves (TW) in a Structures for Lossless Ion Manipulations (SLIM), module having a 44 cm path length and 16 90 turns: The performance of the TW-SLIM module was evaluated for ion transmission and IM separations with different RF, TW parameters, and SLIM :surface gaps in conjunction with mass spectrometry. In this work, TWs were created by-the transient and dynamic application of DC potentials. The module demonstrated highly robust performance and, even with 16 closely spaced,turns, achieving IM resolution performance and ion transmission comparable to a similar Straight path modulo. We found an IM peak Capacity of similar to 31 and peak generation rate of 780 s(-1) for TW speeds of similar to 80 m/s, using the current multi-turn TW-SLIM module, The separations achieved for isomers of peptides and tetrasaccharides were found to comparable to those from a similar to 0.9-m drift tube-based IM-MS platform operated :at the same pressure (4 Torr). The combined: attributes of flexible design, low voltage requirements and lossless ion transmission through multiple turns for the present TW SLIM module provides a basis for SLIM devices capable achieving much greater IM resolution via greatly extended ion path lengths and using compact serpentine designs.