Multifunctional Gadolinium-Doped Manganese Carbonate Nanoparticles for Targeted MR/Fluorescence Imaging of Tiny Brain Gliomas

摘要

Manganese (Mn)-based nanoparticles have been proved to be promising MR. contrast agents for the diagnosis of brain tumors. However, most of them exhibit a low relaxation rate, resulting in an insufficient enhancement effect on tiny gliomas. Herein, we developed gadolinium (Gd)-doped MnCO3 nanoparticles with a size of 11 nm via the thermal decomposition of Mu-oleate in the presence of Gd-oleate. Owing to the small size and Gd doping, these Gd-doped MnCO3 NPs, when endowed with excellent aqueous dispersibility and colloidal stability, exhibited a high r(1) relaxivity of 6.81 mM(-1) s(-1) Moreover, the Gd/MnCO3 NPs were used as a reliable platform to construct a glioma-targeted MR/fluorescence bimodal nanoprobe. The high relaxivity, the bimodal imaging capability, and the specificity nominate the multifunctional Gd doped MnCO3 NPs as an effective nanoprobe for the diagnostic imaging of tiny brain sliomas with an improved efficacy.