Supercritical Fluid Chromatography

摘要

Supercritical fluid chromatography (SFC) has been practiced sporadically for approximately 50 years. Early studies used packed columns with varying degrees of success, and it would be fair to say that SFC did not generate much interest in the separation science community in this period. In the early 1980s, interest in SFC exploded when it was reported that SFC could be easily accomplished with wall coated open tubular columns similar to the columns currently used for gas chromatography. The columns, however, differed in two respects: (a) SFC columns had smaller inner diameters and (b) the polymeric stationary phase that coated the walls was more extensively cross-linked.