Dual-wavelength SERRS for multiplex DNA detection

摘要

Pity those haystack-crawling needle seekers.While they are still out there searching,the analogous problem of finding and quantifying a specific DNA sequence in a mixture of oligos has just gotten easier.Duncan Graham and co-workers at the University of Strathclyde(U.K.)have shown that they can identify up to five individual DNA strands simultaneously at concentrations as low as 10~(-12)M in a heterogeneous mixture with dualwavelength surface-enhanced resonance Raman scattering(SERRS).