Zirconia Stationary Phases for Extreme Separations

摘要

Composite materials surpass standard silicon and carbon for stability and robustness in complicated reversed-phase column applications. Thirty-eight new reversed-phase (RP) columns with various stationary phases were introduced at Pittcon 2001—a stark contrast to the early days of HPLC when, to paraphrase Henry Ford, you could get any kind of column you liked as long as it was an octadecyltrichlorosilane (ODS) modified-silica column (1). Currently, stationary phases for HPLC range from the large family of RPs, including those based on the chemical inertness of zirconia (ZrO_(2)), to highly selective, nearly specific, bioaffinity phases.