Mild Cobalt-Catalyzed Negishi Cross-Couplings of (Hetero)arylzinc Reagents with (Hetero)aryl Halides

摘要

A catalytic system consisting of CoCl(2)2LiCl (5mol%) and HCO2Na (50mol%) enables the cross-coupling of various N-heterocyclic chlorides and bromides as well as aromatic halogenated ketones with various electron-rich and -poor arylzinc reagents. The reactions reached full conversion within a few hours at 25 degrees C.