Copper-Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Carbonyl Formation with Homopropargylic Alcohols

摘要

A novel copper-catalyzed one-pot functionalization of homopropargylic alcohols that involves trifluoromethyla-tion, aryl migration, and formation of a carbonyl moiety has been developed. This reaction constitutes the first direct conversion of homopropargylic alcohols into CF3-containing 3-butenal or 3-buten-l-one derivatives in a regioselective manner. Mechanistic studies indicate that the 1,4-aryl migration proceeds through a radical pathway.