Synthesis of Aryldiazoacetates through Palladiums-Catalyzed Deacylative Cross-Coupling of Aryl Iodides with Acyldiazoacetates

摘要

Palladium(0)-catalyzed deacylative cross-coupling of aryl iodides and acyldiazocarbonyl compounds can be achieved at room temperature under mild reaction conditions. The coupling reaction represents a highly efficient and general method for the synthesis of aryldiazocarbonyl compounds, which have found wide and increasing applications as precursors for generating donor/acceptor-substituted metal-locarbenes.