Enantioselective Copper-Catalyzed Intramolecular Phenolic O-H Bond Insertions Synthesis of Chiral 2-Carboxy Dihydrobenzofurans, Dihydrobenzopyrans, and Tetrahydrobenzooxepines

摘要

The construction of carbon-heteroatom bonds (C-X, where X = N, O, S, etc.) is one of the most widely used methods in organic synthesis. In particular, catalytic asymmetric formation of C-X bonds provides a direct method for the synthesis of chiral compounds containing heteroatoms, and remarkable progress on the intramolecular asymmetric formation of such bonds has been made.