Harnessing Reversible Oxidative Addition: Application of Diiodinated Aromatic Compounds in the Carboiodination Process

摘要

Transition-metal-mediated couplings of halogenated aromat-ics have been extensively studied since the 1960s. Notwithstanding the success of recent aromatic functionalization strategies such as directed ortho metalation and C—H functionalization, Pd-catalyzed aromatic carbon-halogen bond functionalization remains a central strategy. In this regard, the application of polyhalogenated aromatic compounds in site-selective transformations is one of the remaining challenges in this field, due to overcoupling and chemoselectivity issues.