Building Fluorescent DNA Nanodevices on Target Living Cell Surfaces

摘要

The cell membrane is the interface of the intracellular and extracellular environments, where intracellular biological activities are regulated through signal transduction between membrane-bound receptors and signaling molecules, including hormones, neurotransmitters, or therapeutics from complex extracellular environments.In situ analysis and regulation of these key role players is necessary for both 1) a complete, comprehensive understanding of biological pathways with high spatial and temporal resolution and 2) specific biological and therapeutic applications. Previous tactics to accomplish these goals have involved cell-surface engineering through genetic approaches and chemical modification.