Semiconducting Polymer Nanoprobe for In Vivo Imaging of Reactive Oxygen and Nitrogen Species

摘要

The elevated generation of reactive oxygen and nitrogen species (RONS) is a hallmark of many pathological processes ranging from acute and chronic bacterial infections to chronic diseases such as cancer, cardiovascular disease, and arthritis. Therefore, the ability to detect the generation of RONS as pathological chemical messengers is critical to both understanding the etiology of these diseases and optimizing therapeutic interventions. Many fluorescent RONS sensing probes have been developed including small-molecule fluorophores, genetically encoded proteins, single-walled carbon nanotubes (SWCNs), quantum dots (QDs), and dye-conjugated inorganic nanoparticles; however, probes applicable for in vivo imaging are still very limited.