Nonnatural Amino Acid Synthesis by Using Carbon-Hydrogen Bond Functionalization Methodology

摘要

During recent years, transition-metal-catalyzed functionalization of carbon-hydrogen bonds has become a rapidly expanding area of research. Functionalization of the C—H bond is appealing, because it allows for shorter and simpler reaction pathways. However, most of the reports that deal with the conversion of carbon-hydrogen bonds into carbon-carbon bonds involve either method development or mechanistic investigations. Their applications in the synthesis of natural products, or their analogues, are rare. The limited use of C-H bond functionalization may be explained by the following issues. First, methods that result in the functionalization of C-H bonds of alkanes are relatively rare. Second, harsh reaction conditions are typically used that may be incompatible with sensitive functionalities. Third, methods are often not broadly applicable and require nonremovable directing groups.