Palladium-Catalyzed Direct C-H Arylation of Enamides with Simple Arenes

摘要

The realm of transition-metal-catalyzed cross-coupling reactions has traditionally depended on prefunctionalized substrates for both reactivity and selectivity. The quest for improved atom economy and efficiency has brought forward revolutionary changes and important advances especially in the palladium-catalyzed direct C—H functionalization where one or ideally both coupling partners could be replaced with simple arenes/alkenes. A vast majority of these tandem C—H activation reactions are devoted on the synthesis of biaryl motifs.