Elansolid A, a Unique Macrolide Antibiotic from Chitinophaga sancti Isolated as Two Stable Atropisomers

摘要

Bacterial species of the genera Flexibacter and Chitinophaga are known to produce biologically active peptides of relevance to anti-infective research because of their interesting mechanisms of action. For instance, the formadicins, monocyclic β-lactam antibiotics from Flexibacter alginoliquefaciens, act selectively against pseudomonads and have proven to be hydrolysis-resistant against various types of β-lactamases. The anti-MRSA dipeptides TAN-1057A-D isolated from Flexibacter sp. were shown to inhibit peptide elongation during the bacterial translation.