Selective Inhibition of Human Brain Tumor Cells through Multifunctional Quantum-Dot-Based siRNA Delivery

摘要

One of the most promising new chemotherapeutic strategies is the RNA interference (RNAi)-based approach, wherein small double-stranded RNA molecules can sequence-specif-ically inhibit the expression of targeted oncogenes.'11 In principle, this method has high specificity and broad applicability for chemotherapy. For example, the strategy of small interfering RNA (siRNA) enables manipulation of key oncogenes that modulate signaling pathways and thereby regulate the behavior of malignant tumor cells.