Amplification of the Cotton Effect of a Single Chromophore through Liposomal Ordering-Stereochemical Assignment of Plakinic Acids I and J

摘要

Circular dichroism (CD) is a powerful tool for assigning the configuration in natural products,however, its use for acyclic molecules is limited by motional averaging that may reduce or eliminate Cotton effects. Recently, we reported the application of liposomal exciton-coupled CD (L-ECCD) for the determination of both the relative and absolute configuration of acyclic 1,n-diols (n>5) which exploited two properties: dual chromophores with very large electronic-charge-transition dipole moments and ordering of the long-chain carbon backbones within uniform unilamellar liposomes.