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Synthesis and characterization of a pH-responsive poly(ethylene glycol)-based hydrogel: acid degradation, equilibrium swelling, and absorption kinetic characteristics

机译:pH响应型聚乙二醇基水凝胶的合成与表征:酸降解,平衡溶胀和吸收动力学特性

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We developed a pH-responsive, hydrogel based on poly(ethylene glycol) (PEG) covalently cross-linked with acrylic acid and N',N'-dimethylacrylamide along with acid-labile groups. In the hydrogel, PEG plays a role as the key constituent. If its chains break, the polymer networks are destroyed. The pharmacological potential of these hydrogels were demonstrated by determining their water transport profile, modulus of elasticity, and cytotoxicity assay. The hydrogels showed a pseudo-Fickian behavior, a transport mechanism that occurs when the diffusion coefficient changes with the time and the swelling equilibrium is never fully reached. At pH 2, the PEG-richer hydrogels degraded and the scanning electron microscopy (SEM) images illustrated less-defined shapes than at pH 7 and 10. This morphological characteristic results of the hydrogel deconstruction owing to cleavage of ether bonds of the PEG chains unmaking its 3D polymer network. The proposed hydrogels were shown to be compatible to cells, indicating acceptable biocompatibility and an appropriate level of security for use in the biological environments. Furthermore, they showed structural changes in their polymer network in response to pH, which is an important characteristic for stimuli-triggered release of guest molecules.
机译:我们开发了一种基于pH值的水凝胶,该水凝胶基于与丙烯酸和N',N'-二甲基丙烯酰胺以及对酸不稳定的基团共价交联的聚(乙二醇)(PEG)。在水凝胶中,PEG扮演着关键角色。如果其链断裂,则聚合物网络被破坏。这些水凝胶的药理学潜力通过确定其水传输特性,弹性模量和细胞毒性试验得以证实。水凝胶表现出拟菲克(Fickian)行为,这是一种扩散机理,当扩散系数随时间变化而从未完全达到溶胀平衡时发生。在pH 2下,富含PEG的水凝胶降解,扫描电子显微镜(SEM)图像显示的形状比pH在7和10时定义的形状更不清晰。该水凝胶解构的形态学特征是由于PEG链中未键合的醚键断裂所致。其3D聚合物网络。所提出的水凝胶显示出与细胞相容,表明可接受的生物相容性和在生物环境中使用的适当安全性水平。此外,它们显示出其聚合物网络响应pH的结构变化,这是刺激触发的客体分子释放的重要特征。

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