Direct Alkenylation of Indoles with α-Oxo Ketene Dithioacetals: Efficient Synthesis of Indole Alkaloids Meridianin Derivatives

摘要

α-Oxo ketene dithioacetals have recently emerged as versatile reagents in the synthesis of heterocycles and aromatic compounds, as well as odorless thiol equivalents. Indole derivatives are potentially bioactive and have been used as synthons of complex molecules. Recently, bisindoles have attracted interest because of their potent antitumor bioactiv-ity. Although alkylation and arylation of indoles have been well-documented, there are only a few reports on their alkenylation.