Palladium-Catalyzed Three-Component Approach to Promazine with Formation of One Carbon-Sulfurand Two Carbon-Nitrogen Bonds

摘要

The formation of aromatic carbon-heteroatom bonds has traditionally been achieved by nucleophilic aromatic substitution or by the copper-mediated Ullman reaction.The former type of chemistry is generally limited to activated substrates,whereas the latter often requires prolonged heating in the presence of excess copper salts.The palladium-catalyzed formation of aromatic C-N bonds,extensively developed by the groups of Hartwig and Buchwald,has provided a powerful alternative.