A Chiral Hypervalent Iodine(III) Reagent for Enantioselective Dearomatization of Phenols

摘要

Asymmetric induction by hypervalent iodine reagent control is challenging work. Many efforts have been devoted to the design of new chiral reagents with the aim of achieving asymmetric oxidations with high stereoselectivities. However, no effective chiral hypervalent iodine compounds have been reported thus far. We report herein a promising new chiral hypervalent iodine(III) reagent ((R)-9), having a rigid spirobiindane backbone, for the first enantioselective dearomatization of phenols [Eq. (1)]. The use of this chiral reagent also provides important mechanistic insights into the dearomatization processes of phenols induced by hypervalent iodine(III) reagents.