Intramolecular'Hydroiminiumation'of Alkenes:Application to the Synthesis of Conjugate Acids of Cyclic Alkyl Amino Carbenes (CAACs)

摘要

Nitrogen-containing heterocyclic systems have attracted considerable interest over the years because they form the core structures,and are key intermediates,of natural prod ucts.One of the most appealing synthetic approaches for their preparation is the intramolecular hydroamination of alkenes,in which the nitrogen-carbon bond is formed by addition of an amine to an olefin.