Synthesis,characterization and in vitro degradation of biodegradable polyesteramide based on lactic acid

摘要

A new type of biodegradablepolyesteramide P(LA/AU) based on lactic acid and aminoundecanoic acid was synthesized by the melt polycondensation method The copolymers obtained were characterized by FTIR ~1H-NMR,DSC and XRD The in vitro degradation behavior of the copolymers was studied using weighing ~1H-NMR FTIR DSC and SEM With the increase in aminoundecanoic acid units the melting temperature adn crystallinity increased but the water absorption and degradatin rate decreased accordingly During degradation in vitro the ester moiety decreased due to ester cleavage along the macromolecular main chain As degradatin proceeded the melting temperature and crystallinity increased at first then started to decrease because the crystalline phase was destroyed.