Parathyroid hormone-related protein stimulates plasma renin activity via its anorexic effects on sodium chloride intake

摘要

Renin is the rate-limiting enzyme of the renin-angiotensin system, which is integral for the maintenance of normal blood pressure and volume homeostasis (13, 22, 45). Renin secretion is elevated by decreased sodium chloride (NaCl) intake (5, 10, 24), decreased blood pressure or renal perfusion (36, 41), and increased sympathetic nervous activity (43). In vivo, the enzymatic activity of renin is typically quantified as plasma renin activity (PRA) or its ability to generate angiotensin I (Ang I).